Two sample MR report
TPM1_Endothelial Cell (Endo) against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 4 | 0.0388819 | 2.2139622 | 0.9875827 |
| Weighted median | 4 | -0.0983792 | 0.0507640 | 0.0526266 |
| Inverse variance weighted | 4 | -0.0988773 | 0.0447888 | 0.0272696 |
| Simple mode | 4 | -0.0977621 | 0.0677945 | 0.2449673 |
| Weighted mode | 4 | -0.0979203 | 0.0686137 | 0.2488234 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.0129457 | 2 | 0.9935480 |
| Inverse variance weighted | 0.0168190 | 3 | 0.9994228 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0554316 | 0.8906734 | 0.9560353 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 6.45e-05 | 0 | TRUE | 0.4453272 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
